Synthesis, Characterization, Anti-inflammatory, and Antioxidant Activities of Some New Thiazole Derivatives

A series of novel thiazole derivatives (A, A1, A2) were synthesized starting from 1-(3-methoxy phenyl) ethanone and thiourea. The compound (A) was obtained by heating 1-(3-methoxy phenyl) ethanone with thiourea in iodine. Compound (A) on treatment with 4-nitrobenzaldehyde afforded (Z)-4-(3-methoxyphenyl)-N-(4-nitrobenzylidene) thiazole-2-amine (A1). Acylation of compound (A) with 4-nitrobenzoyl chloride to obtain the corresponding N-[4(3-methoxyphenyl) thiazole-2-yl]-4-nitrobenzamid (A2). The structures of compounds have been established by means of FTIR and 1 H-NMR spectral analysis. All thiazole derivatives were evaluated for anti-inflammatory activity by carrageenan induced Rat hind paw method. Derivative A1 show maximum anti-inflammatory activity. All the derivatives were screened for their in vitro antioxidant properties, through total antioxidant capacity, (1, 1diphenyl-2-picryl-hydrazyl) DPPH, Nitric oxide, lipid peroxide scavenging and reducing power. The highest activity was detected during the radicals scavenging, with A1 and A2 noticed as the most active.